Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function. Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening. Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia. One-carbon metabolism nutrients impact the interplay between DNA methylation and gene expression in liver, enhancing protein synthesis in Atlantic salmon. Citizen neuroscience: Wearable technology and open software to study the human brain in its natural habitat. Multi-organ single-cell RNA sequencing in mice reveals early hyperglycemia responses that converge on fibroblast dysregulation. Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity. Sex-specific association of visceral and subcutaneous adipose tissue volumes with systemic inflammation and innate immune cells in people living with obesity. Radiomic features define risk and are linked to DNA methylation attributes in primary CNS lymphoma. The effect Jennifer Nicole Lee Jnl Blowjob leptin on trained innate immunity and on systemic inflammation in subjects with obesity. Endogenous adenine mediates kidney injury in diabetic models and predicts diabetic kidney disease in patients. Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis. Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation. LIQUORICE: detection of epigenetic signatures in liquid biopsies based on whole-genome sequencing data. Epigenetic regulation of T cell lineages in skin and blood following hematopoietic stem cell transplantation. Comparative analysis of genome-scale, base-resolution DNA methylation profiles across animal species. Acknowledging and citing core facilities: Key contributions to data lifecycle should be recognised in the scientific literature: Key contributions to data lifecycle should be recognised in the scientific literature. A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation. Gruffi: an algorithm for computational removal of stressed cells from brain organoid transcriptomic datasets. Validation and functional characterization of GWAS-identified variants for chronic lymphocytic leukemia: a CRuCIAL study. Comprehensive Analysis of Nasal Polyps Reveals a More Pronounced Type 2 Transcriptomic Profile of Epithelial Cells and Mast Cells in Aspirin-Exacerbated Respiratory Disease. Emergence of SARS-CoV-2 Alpha lineage and its correlation with quantitative wastewater-based epidemiology data. Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes. Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function Valentina Stolz, Rafael de Freitas E Silva, Ramona Rica, Ci Zhu, Teresa Preglej, Patricia Hamminger, Daniela Hainberger, Marlis Alteneder, Lena Müller, Monika Waldherr, Darina Waltenberger, Anastasiya Hladik, Benedikt Agerer, Michael Schuster, Tobias Frey, Thomas Krausgruber, Sylvia Knapp, Clarissa Campbell, Klaus Schmetterer, Michael Trauner, Andreas Bergthaler, Christoph Bock, Nicole Jennifer Nicole Lee Jnl Blowjob, Wilfried Ellmeier. Insights into the multifaceted role of interleukin on human immune cell regulation Lisa U Teufel, Vasiliki Matzaraki, Lukas Folkman, Rob Ter Horst, Simone J C F M Moorlag, Catharina M Mulders-Manders, Mihai G Netea, Thomas Krausgruber, Leo A B Joosten, Rob J W Arts. Clin Immunol. Epub Sep GPT-4 as a biomedical simulator Moritz Schaefer, Stephan Reichl, Rob Ter Horst, Adele M Nicolas, Thomas Krausgruber, Francesco Piras, Peter Stepper, Christoph Bock, Matthias Samwald. Comput Biol Med. Epub Jun Targeting T cell plasticity in kidney and gut inflammation by pooled single-cell CRISPR screening Leon U B Enk, Malte Hellmig, Kristoffer Riecken, Christoph Kilian, Paul Datlinger, Saskia L Jauch-Speer, Tobias Neben, Zeba Sultana, Varshi Sivayoganathan, Alina Borchers, Hans-Joachim Paust, Yu Zhao, Nariaki Asada, Shuya Liu, Theodora Agalioti, Penelope Pelczar, Thorsten Wiech, Christoph Bock, Tobias B Huber, Samuel Huber, Stefan Bonn, Nicola Gagliani, Boris Fehse, Ulf Panzer, Jennifer Nicole Lee Jnl Blowjob F Krebs. Sci Immunol. Mapping the brain's gene-regulatory maze Gaia Novarino, Christoph Bock. Epub May JAK-STAT signaling maintains homeostasis in T cells and macrophages Nikolaus Fortelny, Matthias Farlik, Victoria Fife, Anna-Dorothea Gorki, Caroline Lassnig, Barbara Maurer, Katrin Meissl, Marlies Dolezal, Laura Boccuni, Aarathy Ravi Sundar Jose Geetha, Mojoyinola Joanna Akagha, Anzhelika Karjalainen, Stephen Shoebridge, Asma Farhat, Ulrike Mann, Rohit Jain, Shweta Tikoo, Nina Zila, Wolfgang Esser-Skala, Thomas Krausgruber, Katarzyna Sitnik, Thomas Penz, Anastasiya Hladik, Tobias Suske, Sophie Zahalka, Martin Senekowitsch, Daniele Barreca, Florian Halbritter, Sabine Macho-Maschler, Wolfgang Weninger, Heidi A Neubauer, Richard Moriggl, Sylvia Knapp, Veronika Sexl, Birgit Strobl, Thomas Decker, Mathias Müller, Christoph Bock. Nat Immunol. Epub Apr Hyperactive STAT5 hijacks T cell receptor signaling and drives immature T cell acute lymphoblastic leukemia Tobias Suske, Helena Sorger, Gabriele Manhart, Frank Ruge, Nicole Prutsch, Mark W Zimmerman, Thomas Eder, Diaaeldin I Abdallah, Barbara Maurer, Christina Wagner, Susann Schönefeldt, Katrin Spirk, Alexander Pichler, Tea Pemovska, Carmen Schweicker, Daniel Pölöske, Emina Hubanic, Dennis Jungherz, Tony Andreas Müller, Myint Myat Khine Aung, Anna Orlova, Ha Thi Thanh Pham, Kerstin Zimmel, Thomas Krausgruber, Christoph Bock, Mathias Müller, Maik Dahlhoff, Auke Boersma, Thomas Rülicke, Roman Fleck, Elvin Dominic de Araujo, Patrick Thomas Gunning, Tero Aittokallio, Satu Mustjoki, Takaomi Sanda, Sylvia Hartmann, Florian Grebien, Gregor Hoermann, Torsten Haferlach, Philipp Bernhard Staber, Heidi Anne Neubauer, Alfred Thomas Look, Marco Herling, Richard Moriggl. J Clin Invest. Nat Commun. Adaptive immune responses are larger and functionally preserved in a hypervaccinated individual Katharina Kocher, Carolin Moosmann, Felix Drost, Christine Schülein, Pascal Irrgang, Philipp Steininger, Jahn Zhong, Johannes Träger, Bernd Spriewald, Christoph Bock, Dirk H Busch, Christian Bogdan, Benjamin Schubert, Thomas H Winkler, Matthias Tenbusch, Ev-Marie Schuster, Kilian Schober. Lancet Infect Dis. Epub Mar 4. Epub Feb Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis Clarice X Lim, Anna Redl, Lisa Kleissl, Ram Vinay Pandey, Carolina Mayerhofer, Thomas El Jammal, Mario Mazic, Karine Gonzales, Nyamdelger Sukhbaatar, Thomas Krausgruber, Christoph Jennifer Nicole Lee Jnl Blowjob, Markus Hengstschläger, Alain Calender, Yves Pacheco, Georg Stary, Thomas Weichhart.
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